文章摘要
吴燕燕,霍玉梅,胡晓.海洋生物源DPP-Ⅳ抑制肽的制备和构效关系的研究进展[J].上海海洋大学学报,2022,31(4):994-1004.
WU Yanyan,HUO Yumei,HU Xiao.Progress in study on preparation and structure-activity relationship of DPP-Ⅳ inhibiting peptides from marine organisms[J].Journal of Shanghai Ocean University,2022,31(4):994-1004.
海洋生物源DPP-Ⅳ抑制肽的制备和构效关系的研究进展
Progress in study on preparation and structure-activity relationship of DPP-Ⅳ inhibiting peptides from marine organisms
投稿时间:2021-10-12  修订日期:2021-12-24
DOI:10.12024/jsou.20211003583
中文关键词: DPP-Ⅳ抑制肽  制备  分离纯化  构效  活性评价
英文关键词: DPP-Ⅳ inhibitory peptide  preparation  isolation and purification  structure-activity  activity evaluation
基金项目:财政部和农业农村部:国家现代农业产业技术体系(CARS-47);广东省基础与应用基础研究基金(2021A1515010833);国家重点研发计划(2019YFD0901903)
作者单位
吴燕燕 中国水产科学研究院南海水产研究所 农业农村部水产品加工重点实验室, 广东 广州 510300 
霍玉梅 中国水产科学研究院南海水产研究所 农业农村部水产品加工重点实验室, 广东 广州 510300
上海海洋大学 食品学院, 上海 201306 
胡晓 中国水产科学研究院南海水产研究所 农业农村部水产品加工重点实验室, 广东 广州 510300 
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中文摘要:
      糖尿病是一种血糖水平慢性增高的代谢性疾病,对人类的生命健康产生严重影响。长期的高血糖症会导致肥胖、高血压等并发症的发生。目前临床用于治疗糖尿病的药物如西他列汀、利格列汀等存在毒副作用较大等问题,开发高效、安全的天然降血糖活性物质成为了当前的研究热点。二肽基肽酶-Ⅳ(dipeptidyl peptidase-Ⅳ,DPP-Ⅳ)抑制肽是一类通过抑制DPP-Ⅳ活性从而达到降血糖作用的生物活性肽。天然食物来源的DPP-Ⅳ抑制肽具有安全性高、毒副作用小、可长期服用等优点,可应用于降血糖功能性食品。海洋生物资源丰富,是制备DPP-Ⅳ抑制肽的重要来源。对国内外海洋生物蛋白源DPP-Ⅳ抑制肽的来源、分离纯化、结构鉴定和功能活性评价进行综述,并对下一步研发应用提出建议,旨在为开发DPP-Ⅳ抑制肽功能性食品提供参考。
英文摘要:
      Diabetes is a metabolic disease with chronically increased blood sugar levels, which has a serious impact on human health. Long-term hyperglycemia may lead to obesity and hypertension. Currently, drugs used clinically to treat diabetes, such as sitagliptin and linagliptin, have problems such as great toxic and side effects. The development of high-efficiency and safe natural hypoglycemic active substances has become a current research hotspot. Dipeptidyl peptidase-Ⅳ inhibitory peptides are a class of biologically active peptides that can reduce blood sugar by inhibiting the activity of DPP-Ⅳ. DPP-Ⅳ inhibitory peptides derived from natural foods have the advantages of high safety, small side effects, long-term use, etc., and can be used in hypoglycemic functional foods. The abundant marine biological resources are an important source for the preparation of DPP-Ⅳ inhibitory peptides. The source, separation and purification, structural identification and functional activity evaluation of DPP-Ⅳ inhibitory peptides from marine biological protein sources at home and abroad were reviewed, and recommendations were proposed for the further development and application, aiming to develop DPP-Ⅳ inhibitory peptide functional foods for reference.
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